Breaking Down Kratom Alkaloids

November 10, 2023

Breaking Down Kratom Alkaloids

Kratom, scientifically known as Mitragyna speciosa, is a botanical substance that has gained popularity for its diverse range of effects, including pain relief, stress reduction, energy, focus, and more. At the heart of kratom's potency lies its alkaloid composition. Alkaloids are naturally occurring compounds found in various plants, and in kratom, they play a crucial role in producing its unique effects on the body.

The two primary alkaloids responsible for kratom's effects are mitragynine and 7-hydroxymitragynine.


Mitragynine is the most abundant alkaloid in kratom and is known for its pain-relieving and energizing properties. The name derives from the name for a bishop’s headgear, the “mitre”, due to the similarity in shape between the kratom leaf and many traditional mitres.


On the other hand, 7-hydroxymitragynine is a more potent alkaloid, albeit present in smaller quantities. It contributes to kratom's analgesic effects and potentially its sedative properties at higher doses.

Other alkaloids

However, kratom contains numerous other alkaloids, albeit in smaller concentrations, which may also contribute to its overall effects. Some of these alkaloids include speciogynine, paynantheine, and speciociliatine, each with its own unique pharmacological profile.

Alkaloids are naturally occurring compounds found in many plants

Why alkaloids are important

The alkaloid composition can vary significantly between different kratom strains and even among batches of the same strain. This variability is what gives rise to the diverse effects observed among various kratom products. For example, red vein kratom strains are often associated with sedative and pain-relieving effects, while white vein strains are reputed for their stimulating and mood-enhancing properties.

Understanding kratom's alkaloid profile is essential for consumers seeking to make informed choices about which strains may best suit their needs. However, it's crucial to remember that kratom's effects can vary from person to person due to factors such as individual biochemistry, tolerance, and dosage.

Many researchers believe that kratom's alkaloids are the key to unlocking its therapeutic potential. By understanding the roles of mitragynine, 7-hydroxymitragynine, and other alkaloids, consumers can better inform themselves about kratom's effects and make more informed decisions about its use.